1 Scope
This document specifies a method for the determination of the dissolved fraction of
selected active pharmaceutical ingredients and transformation products, as well as
other organic substances (see Table 1) in drinking water, ground water, surface water and treated waste water.
The lower application range of this method can vary depending on the sensitivity of
the equipment used and the matrix of the sample. For most compounds to which this
document applies, the range is ≥ 0,025 µg/l for drinking water, ground water and surface
water, and ≥ 0,050 µg/l for treated waste water.
The method can be used to determine further organic substances or in other types of
water (e.g. process water) provided that accuracy has been tested and verified for
each case, and that storage conditions of both samples and reference solutions have
been validated. Table 1 shows the substances for which a determination was tested in accordance with the
method. Table E.1 provides examples of the determination of other organic substances.
Table 1
—
Substances for which a determination was tested in accordance with this method
|
Common name
Chemical name (IUPAC a ) |
Molecular
formula |
Molar
mass |
CAS-RN b |
|---|---|---|---|
| g/mol | |||
| 4-Acetylaminoantipyrine
N-(2,3-Dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)acetamide
|
C13H15N3O2 | 245,28 | 83-15-8 |
| N4-Acetyl sulfamethoxazole
N-{4-[(5-Methyl-1,2-oxazol-3-yl)sulfamoyl]phenyl}-acetamide
|
C12H13N3O4S | 295,32 | 21312-10-7 |
| Diatrizoic acid (amidotricoic acid)
3,5-Bis(acetamido)-2,4,6-triiodobenzoic acid
|
C11H9I3N2O4 | 613,91 | 117-96-4 |
| Atenolol
(RS)-2-[4-[2-Hydroxy-3-(1-methylethylamino) propoxy]phenyl]ethanamide
|
C14H22N2O3 | 266,34 | 29122-68-7 |
| Bezafibrate
2-{4-[2-(4-Chlorbenzamido)ethyl]phenoxyl}-2-
methylpropanoic acid |
C19H20ClNO4 | 361,80 | 41859-67-0 |
| Bisoprolol
(RS)-1-[4-(2-Isopropoxyethoxymethyl)phenoxy]-3-
isopropylamino-2-propanol |
C18H31NO4 | 325,45 | 66722-44-9 |
| Carbamazepine
5H-Dibenzo[b,f]azepine-5-carbamide
|
C15H12N2O | 236,27 | 298-46-4 |
| Clarithromycin
(2R,3R,4S,5R,8R,9S,10S,11R,12R,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-5-ethyl-3,4-dihydroxy-9-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl]oxy-12-methoxy-2,4,8,10,12,14-hexa-
methyl-6-oxacyclotetradecane-1,7-dione |
C38H69NO13 | 747,95 | 81103-11-9 |
| Clofibric acid
2-(4-Chlorophenoxy)-2-methylpropanoic acid
|
C10H11ClO3 | 214,70 | 882-09-7 |
| Dehydrato-Erythromycin (anhydro-erythromycin)
(2R,3R,4S,5S,8R,9S,10S,11R,12R)-11-{[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-5-ethyl-3-hydroxy-9-[(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy]-2,4,8,10,12,14-hexamethyl-6,15,16-trioxatricyclo[10.2.1.1{1,4}]hexadecane-7-one
|
C37H65NO12 | 715,91 | 23893-13-2 |
| Diazepam
(RS)-7-Chlor-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-
benzodiazepine-2-on |
C16H13ClN2O | 284,74 | 439-14-5 |
| Diclofenac
2-[2-[(2,6-Dichlorphenyl)amino]phenyl]acetic acid
|
C14H11Cl2NO2 | 296,15 | 15307-86-5 |
| 10,11-Dihydro-10,11-dihydroxy carbamazepine
(5S,6S)-5,6-Dihydroxy-5,6-dihydrobenzo[b][1]benzazepie-11-carboxamide
|
C15H14N2O3 | 270,29 | 58955-93-4 |
| Erythromycin
6-(4-Dimethylamino-3-hydroxy-6-methyl-oxan-2-yl)oxy-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl)-oxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione
|
C37H67NO13 | 733,93 | 114-07-8 |
| 4-Formylaminoantipyrine
N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)formamide
|
C12H13N3O2 | 231,25 | 1672-58-8 |
| Gemfibrozil
5-(2,5-Chlorophenoxy)-2,2-methylpropanoic acid
|
C15H22O3 | 250,34 | 25812-30-0 |
| Ibuprofen
(RS)-2-[4-(2-Methylpropyl)phenyl]propanoic acid
|
C13H18O2 | 206,28 | 15687-27-1 |
| Iomeprol
(±)-N,N′-Bis-(2,3-dihydroxypropyl)-5-[(2-hydroxy-acetyl)methylamino]-2,4,6-triiodo
isophthalamide
|
C17H22I3N3O8 | 777,09 | 78649-41-9 |
| Iopamidol
(S)-N,N′-Bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxypropanoyl)amino]-2,4,6-triiodobenzene-1,3-dicarbamide
|
C17H22I3N3O3 | 777,08 | 60166-93-0 |
| Iopromide
(±)-N,N′-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-
(2-methoxyacetamido)-N-methylisophthalamide |
C18H24I3N3O8 | 791,12 | 73334-07-3 |
| Metoprolol
(RS)-1-(Isopropylamino)-3-[4-(2-methoxyethyl) phenoxy]propan-2-ol
|
C15H25NO3 | 267,36 | 37350-58-6 |
| Naproxen
(S)-2-(6-Methoxy-2-naphthyl)propanoic acid
|
C14H14O3 | 230,26 | 22204-53-1 |
| Oxazepam
(RS)-7-Chloro-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-
benzodiazepin-2-on |
C15H11ClN2O2 | 286,71 | 604-75-1 |
| Phenazone
1,5-Dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-on
|
C11H12N2O | 188,23 | 60-80-0 |
| Primidone
5-Ethyl-5-phenylhexahydropyrimidin-4,6-dione
|
C12H14N2O2 | 218,25 | 125-33-7 |
| Propyphenazone
1,5-Dimethyl-4-(1-methylethyl)-2-phenyl-1,2-dihydro-3H-
pyrazol-3-one |
C14H18N2O | 230,31 | 479-92-5 |
| Roxithromycin
(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-10-(2,4,7-trioxa-1-azaoctan-1-ylidene)-1-
oxacyclotetradecane-2-one |
C41H76N2O15 | 837,05 | 80214-83-1 |
| Sotalol
(RS)-4′-(1-Hydroxy-2-isopropylaminoethyl)
methanesulfonanilide |
C12H20N2O3S | 272,36 | 3930-20-9 |
| Sulfamethoxazole
4-Amino-N-(5-methyl-1,2-oxazol-3-yl)benzene-sulfonamide
|
C10H11N3O3S | 253,28 | 723-46-6 |
| Temazepam
(RS)-7-Chloro-3-hydroxy-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
|
C16H13ClN2O2 | 300,74 | 846-50-4 |
| Trimethoprim
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
|
C14H18N4O3 | 290,32 | 738-70-5 |