1 Scope
This International Standard provides criteria for quality assurance and quality control, evaluation of the performance, and the accreditation of biological dosimetry by
cytogenetic service laboratories.
This International Standard addresses
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a) the confidentiality of personal information, for the customer and the service laboratory,
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b) the laboratory safety requirements,
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c) the calibration sources and calibration dose ranges useful for establishing the reference dose-effect curves that contribute to the dose estimation from chromosome aberration frequency and the minimum resolvable doses,
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d) the scoring procedure for unstable chromosome aberrations used for biological dosimetry,
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e) the criteria for converting a measured aberration frequency into an estimate of absorbed dose,
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f) the reporting of results,
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g) the quality assurance and quality control,
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h) informative annexes containing sample instructions for customer, sample questionnaire, sample of report, fitting of the low dose-response curve by the method of maximum likelihood and calculating the error of dose estimate, odds ratio method for cases of suspected exposure to a low dose, and sample data sheet for recording aberrations.